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Essentials

Effect of Ultrasound Application on Fat Mobilization

Clinical Study held in Osaka, Japan 2007
Osaka Medical Centre and Research Insitute

Introduction
There are numerous reports that norepinephrine-induced lipolysis in fat cells prevents obesity. With knowledge that catecholamines (epinephrine and norepinephrine) stimulate fat cell lipolysis, we hypothesize that hydrolysis of triglyceride in fat cells and the successive fat mobilization stimulated by catecholamines are essential for reduction of stored triglyceride in adipose tissues, and results in reduction of obesity. We speculate that application of ultrasound stimulates lipolysis in adipose tissue by increasing secretion of norepinephrine, and the irradiation of ultrasound frequency may cause lipolysis, and consequently inch loss in the treated area. To clarify whether or not irradiation of ultrasound to abdominal area caused fat mobilization, we examine the changes of plasma Free Fatty Acids (FFA), epinephrine and norepinephrine, and the secretions of norepinephrine from sympathetic nerve in peripheral adipose tissues after ultrasound irradiation under the various conditions.

Materials and Methods
Three groups of ten men were used in this clinical study which spanned over 10 days.

Group A: Ultrasound irradiation of 1000kHz, 10 minutes a day.
Group B: Ultrasound irradiation of 500kHz, 10 minutes a day.
Group C: Control Group, no ultrasound administered.

All thirty men were required to walk for at a speed of 100m/min on the treadmill for 10 minutes each day. The site of ultrasound treatment was on the inner right thigh. The left thigh served as a control.

After walking and ultrasound treatment, the thickness of fat in the left and right thighs were measured using ultrasonography (SSD 500B, Aloka Co., Tokyo, Japan).

Results
After 10 days of exercise, the fat thickness of the non-irradiated left leg did not change as compared to that of before exercise. On the other hand, the fat thickness of ultrasound-irradiated right leg was reduced by the combination of exercise for 10 days and ultrasound-irradiation for 10 minutes as compared with the control leg (non-irradiated right leg).

Ultrasound Irradiation FrequencyMean Difference (mm)1
Control (non-irradiated)+0.36
500kHz-2.02
1000kHz-2.79
1 The mean difference of fat thickness of legs was determined by the differences before and after the exercise with or without ultrasound irradiation.

Discussion
The effects of the combination of ultrasound irradiation and exercise on the subcutaneous fat thickness of thighs in human were examined in this study. Adult men were divided into three groups; [Group A] 10 minutes irradiation of 1000kHz frequency and 10 minutes walking, [Group B] 10 min irradiation of 500 kHz frequency and 10 minutes walking, and [Group C] 10 minutes walking without ultrasound irradiation. The irradiation and walking were carried out once a day for 10 days. The site of ultrasound irradiation was the inner right thigh with the left side used as a control.

We found that the subcutaneous fat thickness of the irradiated (right) thighs significantly decreased compared with that of the non-irradiated (left) thighs after irradiation. Body weight between before and after exercise and ultrasound irradiation was not changed.

Application of ultrasound caused increases in plasma FFA and norepinephrine concentration of extra-cellular fluid of perirenal adipose tissue. These results suggest that ultrasound application stimulates fat mobilization through a local increase in norepinephrine secretion under the conditions of effective frequency and intensity (1000kHz).

Therefore, we conclude that Evita Slimsonic, designed for lipolysis of body fat for personal use, which irradiates ultrasound frequency of 800kHz is considered to be effective for body slimming and reduction of body circumference.

Acknowledgments
Authors wish to express their sincere gratitude for the invaluable sponsorship, suggestions and discussions from independent sponsors, the Japan School of Medicine, specifically the Department of Preventive Medicine and Tokyo Obesity Research Lab.

Authors
Reviewed by: Herohiide Miwa, Maesato Kinoa, Li-Kun Haanb, Kuniihiro Takakac, Takahiro Tsujita, Hiroshi Furuhaetad, Maesahiro Sugiyame, Hiromaesa Senof, Yusuike Morita, Yoshi Kimura, Hirochi Oku.

Study Concluded: 2007. Osaka, Japan.

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